RESEARCH INTEREST: Biomedical Big Data Analytics: Complex high-dimensional data from high-throughput technologies. ? Statistical Methods and Theories for Differential Equation Models. ? High-dimensional data analysis and inference ? Computational Systems Biology and Bioinformatics: Genetic and protein network and multi-scale modeling. ? Immunological Data Analysis and Modeling: Modeling immune response to influenza and HIV infection. ? Biomathematical Modeling: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS epidemics. ? Clinical Trials: Clinical trial design, pharmacokinetics and pharmacodynamics (PK/PD) study and Phase I trial design and modeling. 3 ? Longitudinal Data: Nonparametric regression methods and mixed-effects models. ? Other Statistical Methodologies: High-dimensional variable selection, Markov chain Monte Carlo (MCMC), Bayesian methods, state-space models, measurement error models, missing data, and spatial statistics.